New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay

New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay

Abstract Background Gene mutation assays in transgenic rodents are useful tools to investigate in vivo mutagenicity in a target tissue. Using a lambda EG10 transgene containing reporter genes, gpt delta transgenic mice and rats have been developed to detect point mutations and deletions. The transge...

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Bibliographic Details
Main Authors: Kenichi Masumura, Tomoko Ando, Akiko Ukai, Sho Fujiwara, Shigeo Yokose, Xinyue You, Takayoshi Suzuki, Hiroyuki Hayashi, Takehiko Nohmi, Hisayoshi Takagi, Masamitsu Honma
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Genes and Environment
Subjects:
gpt delta transgenic rat
gpt assay
Spi− assay
mutant frequency
mutation spectrum
Online Access:https://doi.org/10.1186/s41021-021-00195-1

Internet

https://doi.org/10.1186/s41021-021-00195-1

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