Multi-Domain Touchscreen-Based Cognitive Assessment of C57BL/6J Female Mice Shows Whole-Body Exposure to 56Fe Particle Space Radiation in Maturity Improves Discrimination Learning Yet Impairs Stimulus-Response Rule-Based Habit Learning

Multi-Domain Touchscreen-Based Cognitive Assessment of C57BL/6J Female Mice Shows Whole-Body Exposure to 56Fe Particle Space Radiation in Maturity Improves Discrimination Learning Yet Impairs Stimulus-Response Rule-Based Habit Learning

Astronauts during interplanetary missions will be exposed to galactic cosmic radiation, including charged particles like 56Fe. Most preclinical studies with mature, “astronaut-aged” rodents suggest space radiation diminishes performance in classical hippocampal- and prefrontal cortex-dependent tasks...

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Bibliographic Details
Main Authors: Ivan Soler, Sanghee Yun, Ryan P. Reynolds, Cody W. Whoolery, Fionya H. Tran, Priya L. Kumar, Yuying Rong, Matthew J. DeSalle, Adam D. Gibson, Ann M. Stowe, Frederico C. Kiffer, Amelia J. Eisch
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
dentate gyrus
prefrontal cortex
striatum
hippocampus
behavioral pattern separation
rodent touchscreen
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2021.722780/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2021.722780/full

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