Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency

Peripheral Innate Immune Activation Correlates With Disease Severity in GRN Haploinsufficiency

Objective: To investigate associations between peripheral innate immune activation and frontotemporal lobar degeneration (FTLD) in progranulin gene (GRN) haploinsufficiency.Methods: In this cross-sectional study, ELISA was used to measure six markers of innate immunity (sCD163, CCL18, LBP, sCD14, IL...

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Bibliographic Details
Main Authors: Peter A. Ljubenkov, Zachary Miller, Paige Mumford, Jane Zhang, Isabel Elaine Allen, Laura Mitic, Adam Staffaroni, Hilary Heuer, Julio C. Rojas, Yann Cobigo, Anna Karydas, Rodney Pearlman, Bruce Miller, Joel H. Kramer, Michael S. McGrath, Howard J. Rosen, Adam L. Boxer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neurology
Subjects:
progranulin (GRN)
frontotemperal lobar degeneration
monocyte
innate immune system
peripheral immune activation
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.01004/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.01004/full

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