Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity

Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity

Acidity and hypoxia are crucial phenotypes of tumour microenvironment both contributing to the selection of malignant cells under a micro evolutionistic pressure. During the tumour progression, nanovesicles, called exosomes and the metalloenzyme carbonic anhydrase IX (CA IX) affect the tumour growth...

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Bibliographic Details
Main Authors: Mariantonia Logozzi, Clemente Capasso, Rossella Di Raimo, Sonia Del Prete, Davide Mizzoni, Mario Falchi, Claudiu T. Supuran, Stefano Fais
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
tumour microenvironment
carbonic anhydrase ix
cancer
exosomes
lncap
Online Access:http://dx.doi.org/10.1080/14756366.2018.1538980

Internet

http://dx.doi.org/10.1080/14756366.2018.1538980

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