Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57<sup>KIP2 </sup>and Cdk2

Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57<sup>KIP2 </sup>and Cdk2

<p>Abstract</p> <p>Background</p> <p>Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in genes <it>PKD1 </i...

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Bibliographic Details
Main Authors: Li Li, Bai Chang-Xi, Witzgall Ralph, Kastanos Evdokia, Koupepidou Panayiota, Felekkis Kyriacos N, Tsiokas Leonidas, Gretz Norbert, Deltas Constantinos
Format: Article
Language:English
Published: BMC 2008-08-01
Series:BMC Nephrology
Online Access:http://www.biomedcentral.com/1471-2369/9/10

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http://www.biomedcentral.com/1471-2369/9/10

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