Metabolic Stability of New Mito-Protective Short-Chain Naphthoquinones

Metabolic Stability of New Mito-Protective Short-Chain Naphthoquinones

Short-chain quinones (SCQs) have been identified as potential drug candidates against mitochondrial dysfunction, which is largely dependent on their reversible redox characteristics of the active quinone core. We recently synthesized a SCQ library of > 148 naphthoquinone derivatives and ident...

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Bibliographic Details
Main Authors: Zikai Feng, Jason A. Smith, Nuri Gueven, Joselito P. Quirino
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Pharmaceuticals
Subjects:
mitochondrial dysfunction
idebenone
short-chain quinone
metabolic stability
hepg2 cell culture
reverse-phase liquid chromatography
Online Access:https://www.mdpi.com/1424-8247/13/2/29

Internet

https://www.mdpi.com/1424-8247/13/2/29

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