Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles

Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles

Aim: Primary human hepatocytes (PHHs) undergo dedifferentiation upon the two-dimensional (2D) culture, which particularly hinders their utility in long-term in vitro studies. Lipids, as a major class of biomolecules, play crucial roles in cellular energy storage, structure, and signaling. Here, for...

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Bibliographic Details
Main Authors: Mostafa Kiamehr, Laura Heiskanen, Thomas Laufer, Aneta Düsterloh, Mustafa Kahraman, Reijo Käkelä, Reijo Laaksonen, Katriina Aalto-Setälä
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:International Journal of Molecular Sciences
Subjects:
primary human hepatocytes (PHHs)
dedifferentiation
lipidomics
mass spectrometry
sphingolipids (SLs)
phospholipids (PLs)
saturated fatty acids (SFAs)
monounsaturated fatty acids (MUFAs)
polyunsaturated fatty acids (PUFAs)
microRNAs (miRNAs)
Online Access:https://www.mdpi.com/1422-0067/20/12/2910

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https://www.mdpi.com/1422-0067/20/12/2910

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