Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis

Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis

α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-mediated excitotoxicity contributes to the selective motor neuron death in amyotrophic lateral sclerosis (ALS). In this study, we investigated the effect of P2 receptor-influencing substances on kainate-induced motor neuron death...

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Bibliographic Details
Main Authors: Maria Andries, Philip Van Damme, Wim Robberecht, Ludo Van Den Bosch
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis (ALS)
AMPA receptor
Motoneuron
Excitotoxicity
ATP
Ivermectin
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002014

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http://www.sciencedirect.com/science/article/pii/S0969996106002014

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