CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit⁺ cells in rats.

CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit⁺ cells in rats.

Successful curative treatment of severe pulmonary arterial hypertension with luminal obliteration will require a thorough understanding of the mechanism underlying the development and progression of pulmonary vascular lesions. But the cells that obliterate the pulmonary arterial lumen in severe pulm...

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Bibliographic Details
Main Authors: Daniela Farkas, Donatas Kraskauskas, Jennifer I Drake, Aysar A Alhussaini, Vita Kraskauskiene, Harm J Bogaard, Carlyne D Cool, Norbert F Voelkel, Laszlo Farkas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3933653?pdf=render

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http://europepmc.org/articles/PMC3933653?pdf=render

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