Case Report: Local Cytokine Release Syndrome in an Acute Lymphoblastic Leukemia Patient After Treatment With Chimeric Antigen Receptor T-Cell Therapy: A Possible Model, Literature Review and Perspective

Case Report: Local Cytokine Release Syndrome in an Acute Lymphoblastic Leukemia Patient After Treatment With Chimeric Antigen Receptor T-Cell Therapy: A Possible Model, Literature Review and Perspective

Chimeric antigen receptor T (CAR-T) cell therapy has achieved remarkable clinical efficacy in treatment of many malignancies especially for B-cell hematologic malignancies. However, the application of CAR-T cells is hampered by potentially adverse events, of which cytokine release syndrome (CRS) is...

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Bibliographic Details
Main Authors: Chengxin Luan, Junjie Zhou, Haixia Wang, Xiaoyu Ma, Zhangbiao Long, Xin Cheng, Xiaowen Chen, Zhenqi Huang, Dagan Zhang, Ruixiang Xia, Jian Ge
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
local cytokine-release syndrome
acute lymphoblastic leukemia
possible model
systemic cytokine-release syndrome
chimeric antigen receptor T therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.707191/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.707191/full

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