Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway

Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway

Gemcitabine resistance will occur by time after the initial response in pancreatic cancer. Ginkgolide B (GB), a major terpene lactone component of Ginkgo biloba leaves, is a highly selective and competitive inhibitor for platelet-activating factor (PAF) receptor. In the present study, we evaluated t...

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Bibliographic Details
Main Authors: Changjie Lou, Haibo Lu, Zhigang Ma, Chao Liu, Yanqiao Zhang
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Pancreatic cancer
Gemcitabine sensitivity
Ginkgolide B (GB)
Nuclear factor kappa b (NF-кB)
Platelet-activating factor receptor (PAFR)
Online Access:http://www.sciencedirect.com/science/article/pii/S075333221834664X

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http://www.sciencedirect.com/science/article/pii/S075333221834664X

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