TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala

TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdala

TMEM16B (ANO2) is the Ca2+-activated chloride channel expressed in multiple brain regions, including the amygdala. Here we report that Ano2 knockout mice exhibit impaired anxiety-related behaviors and context-independent fear memory, thus implicating TMEM16B in anxiety modulation. We found that TMEM...

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Bibliographic Details
Main Authors: Ke-Xin Li, Mu He, Wenlei Ye, Jeffrey Simms, Michael Gill, Xuaner Xiang, Yuh Nung Jan, Lily Yeh Jan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-09-01
Series:eLife
Subjects:
TMEM16B (ANO2)
calcium activated chloride channels (CaCC)
GABAergic transmission
anxiety
fear
Online Access:https://elifesciences.org/articles/47106

Internet

https://elifesciences.org/articles/47106

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