Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a)

Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a)

Lipoprotein (a) [Lp(a)] is a risk factor for CVD and a target of therapy, but Lp(a) measurements are not globally standardized. Commercially available assays generally use polyclonal antibodies that detect multiple sites within the kringle (K)IV2 repeat region of Lp(a) and may lead to inaccurate ass...

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Bibliographic Details
Main Authors: Ayelet Gonen, Xiaohong Yang, Calvin Yeang, Elena Alekseeva, Marlys Koschinsky, Joseph L. Witztum, Michael Boffa, Sotirios Tsimikas
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Journal of Lipid Research
Subjects:
lipoprotein (a)
monoclonal antibody
isoform
kringle
cardiovascular disease
aortic stenosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520436910

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http://www.sciencedirect.com/science/article/pii/S0022227520436910

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