PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes

PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes

The transcriptional coactivators peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and PGC-1β are positive regulators of skeletal muscle mass and energy metabolism; however, whether they influence muscle growth and metabolic adaptations via increased protein synthesis is not clear...

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Bibliographic Details
Main Authors: Erin L. Brown, Victoria C. Foletta, Craig R. Wright, Patricio V. Sepulveda, Nicky Konstantopoulos, Andrew Sanigorski, Paul Della Gatta, David Cameron-Smith, Anastasia Kralli, Aaron P. Russell
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Physiology
Subjects:
PGC-1α
PGC-1β
ERRα
protein synthesis
C2C12 myotubes
muscle mass
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01336/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01336/full

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