H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions

H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions

Mechanisms underlying gene repression and silencers remain poorly understood. Here the authors investigate the role of H3K27me3-rich regions in the genome, as defined from clusters of H3K27me3 peaks, in regulating gene expression via looping.

Bibliographic Details
Main Authors: Yichao Cai, Ying Zhang, Yan Ping Loh, Jia Qi Tng, Mei Chee Lim, Zhendong Cao, Anandhkumar Raju, Erez Lieberman Aiden, Shang Li, Lakshmanan Manikandan, Vinay Tergaonkar, Greg Tucker-Kellogg, Melissa Jane Fullwood
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-20940-y

Internet

https://doi.org/10.1038/s41467-021-20940-y

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