The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease

The emerging role of autophagic-lysosomal dysfunction in Gaucher disease and Parkinson's disease

Gaucher disease (GD), the commonest lysosomal storage disorder, results from the lack or functional deficiency of glucocerebrosidase (GCase) secondary to mutations in the GBA1 gene. There is an established association between GBA1 mutations and Parkinson's disease (PD), and indeed GBA1 mutation...

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Bibliographic Details
Main Authors: Kerri J Kinghorn, Amir M Asghari, Jorge Iván Castillo-Quan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:Neural Regeneration Research
Subjects:
Gaucher disease; Parkinson′s disease; Drosophila; autophagy; lysosome; glucocerebrosidase; GBA
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=3;spage=380;epage=384;aulast=Kinghorn

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=3;spage=380;epage=384;aulast=Kinghorn

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