Sphingosine-1-Phosphate and the S1P3 Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation

Sphingosine-1-Phosphate and the S1P3 Receptor Initiate Neuronal Retraction via RhoA/ROCK Associated with CRMP2 Phosphorylation

The bioactive lipid sphingosine-1-phosphate (S1P) is an important regulator in the nervous system. Here, we explored the role of S1P and its receptors in vitro and in preclinical models of peripheral nerve regeneration. Adult sensory neurons and motor neuron-like cells were exposed to S1P in an in v...

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Bibliographic Details
Main Authors: Serena Quarta, Maria Camprubí-Robles, Rüdiger Schweigreiter, Dusan Matusica, Rainer V. Haberberger, Richard L. Proia, Christine E. Bandtlow, Antonio Ferrer-Montiel, Michaela Kress
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
S1P
S1P3
neurite outgrowth
axonal regeneration
CRMP2
sensory neurons
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00317/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00317/full

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