Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy

Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy

The development of a safeguard system to remove tumorigenic cells would allow safer clinical applications of stem cells for the treatment of patients with an intractable disease including genetic disorders. Such safeguard systems should not disrupt the host genome and should have long-term stability...

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Bibliographic Details
Main Authors: Narumi Uno, Katsuhiro Uno, Shinya Komoto, Teruhiko Suzuki, Masaharu Hiratsuka, Mitsuhiko Osaki, Yasuhiro Kazuki, Mitsuo Oshimura
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
cancer immunotherapy
gene and cell therapy
HAC
MAC
major histocompatibility complex
mammalian artificial chromosome
pluripotent stem cell
regenerative medicine
safeguard system
tumor suppression
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300580

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http://www.sciencedirect.com/science/article/pii/S2162253116300580

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