A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension

During development, organs undergo large scale forces driven by the cytoskeleton but the precise molecular regulation of cytoskeletal networks remains unclear. Here, the authors report a Cdc42-dependent supracellular cytoskeletal network integrates local actomyosin contraction at tissue scale and dr...

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Main Authors:	Anna Popkova, Orrin J. Stone, Lin Chen, Xiang Qin, Chang Liu, Jiaying Liu, Karine Belguise, Denise J. Montell, Klaus M. Hahn, Matteo Rauzi, Xiaobo Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15593-2

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spelling	doaj-d3b75b595c2245e39bc3c0fe1f6b3ca62021-05-11T08:30:59ZengNature Publishing GroupNature Communications2041-17232020-04-0111111510.1038/s41467-020-15593-2A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extensionAnna Popkova0Orrin J. Stone1Lin Chen2Xiang Qin3Chang Liu4Jiaying Liu5Karine Belguise6Denise J. Montell7Klaus M. Hahn8Matteo Rauzi9Xiaobo Wang10LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSDepartment of Pharmacology and Lineberger Cancer Center, University of North Carolina at Chapel HillLBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSLBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSLBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSLBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSLBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSMolecular, Cellular and Developmental Biology Department, University of CaliforniaDepartment of Pharmacology and Lineberger Cancer Center, University of North Carolina at Chapel HillUniversité Côte d’Azur, CNRS, Inserm, iBVLBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPSDuring development, organs undergo large scale forces driven by the cytoskeleton but the precise molecular regulation of cytoskeletal networks remains unclear. Here, the authors report a Cdc42-dependent supracellular cytoskeletal network integrates local actomyosin contraction at tissue scale and drives global tissue elongation.https://doi.org/10.1038/s41467-020-15593-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Anna Popkova Orrin J. Stone Lin Chen Xiang Qin Chang Liu Jiaying Liu Karine Belguise Denise J. Montell Klaus M. Hahn Matteo Rauzi Xiaobo Wang
spellingShingle	Anna Popkova Orrin J. Stone Lin Chen Xiang Qin Chang Liu Jiaying Liu Karine Belguise Denise J. Montell Klaus M. Hahn Matteo Rauzi Xiaobo Wang A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension Nature Communications
author_facet	Anna Popkova Orrin J. Stone Lin Chen Xiang Qin Chang Liu Jiaying Liu Karine Belguise Denise J. Montell Klaus M. Hahn Matteo Rauzi Xiaobo Wang
author_sort	Anna Popkova
title	A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension
title_short	A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension
title_full	A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension
title_fullStr	A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension
title_full_unstemmed	A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension
title_sort	cdc42-mediated supracellular network drives polarized forces and drosophila egg chamber extension
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-04-01
description	During development, organs undergo large scale forces driven by the cytoskeleton but the precise molecular regulation of cytoskeletal networks remains unclear. Here, the authors report a Cdc42-dependent supracellular cytoskeletal network integrates local actomyosin contraction at tissue scale and drives global tissue elongation.
url	https://doi.org/10.1038/s41467-020-15593-2
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A Cdc42-mediated supracellular network drives polarized forces and Drosophila egg chamber extension

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