miR-221 Augments TRAIL-Mediated Apoptosis in Prostate Cancer Cells by Inducing Endogenous TRAIL Expression and Targeting the Functional Repressors SOCS3 and PIK3R1

miR-221 Augments TRAIL-Mediated Apoptosis in Prostate Cancer Cells by Inducing Endogenous TRAIL Expression and Targeting the Functional Repressors SOCS3 and PIK3R1

miR-221 is regarded as an oncogene in many malignancies, and miR-221-mediated resistance towards TRAIL was one of the first oncogenic roles shown for this small noncoding RNA. In contrast, miR-221 is downregulated in prostate cancer (PCa), thereby implying a tumour suppressive function. By using pro...

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Bibliographic Details
Main Authors: Markus Krebs, Christoph Behrmann, Charis Kalogirou, Ioannis Sokolakis, Susanne Kneitz, Marianna Kruithof-de Julio, Eugenio Zoni, Anne Rech, Bastian Schilling, Hubert Kübler, Martin Spahn, Burkhard Kneitz
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2019/6392748

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http://dx.doi.org/10.1155/2019/6392748

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