Common virulence gene expression in adult first-time infected malaria patients and severe cases

Common virulence gene expression in adult first-time infected malaria patients and severe cases

Sequestration of Plasmodium falciparum(P. falciparum)-infected erythrocytes to host endothelium through the parasite-derived P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion proteins is central to the development of malaria pathogenesis. PfEMP1 proteins have diversified and expanded to...

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Bibliographic Details
Main Authors: J Stephan Wichers, Gerry Tonkin-Hill, Thorsten Thye, Ralf Krumkamp, Benno Kreuels, Jan Strauss, Heidrun von Thien, Judith AM Scholz, Helle Smedegaard Hansson, Rasmus Weisel Jensen, Louise Turner, Freia-Raphaella Lorenz, Anna Schöllhorn, Iris Bruchhaus, Egbert Tannich, Rolf Fendel, Thomas D Otto, Thomas Lavstsen, Tim W Gilberger, Michael F Duffy, Anna Bachmann
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
P. falciparum
PfEMP1
RNA-seq
transcriptomics
variant surface antigens
virulence
Online Access:https://elifesciences.org/articles/69040

Internet

https://elifesciences.org/articles/69040

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