Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres.

Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres.

Alternative Lengthening of Telomeres (ALT) is a non-telomerase mechanism of telomere lengthening that occurs in about 10% of cancers overall and is particularly common in astrocytic brain tumors and specific types of sarcomas. Somatic cell hybridization analyses have previously shown that normal tel...

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Bibliographic Details
Main Authors: Kylie Bower, Christine E Napier, Sara L Cole, Rebecca A Dagg, Loretta M S Lau, Emma L Duncan, Elsa L Moy, Roger R Reddel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3502299?pdf=render

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http://europepmc.org/articles/PMC3502299?pdf=render

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