ADH1B and ADH1C genotype, alcohol consumption and biomarkers of liver function: findings from a Mendelian randomization study in 58,313 European origin Danes.

ADH1B and ADH1C genotype, alcohol consumption and biomarkers of liver function: findings from a Mendelian randomization study in 58,313 European origin Danes.

The effect of alcohol consumption on liver function is difficult to determine because of reporting bias and potential residual confounding. Our aim was to determine this effect using genetic variants to proxy for the unbiased effect of alcohol.We used variants in ADH1B and ADH1C genes as instrumenta...

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Bibliographic Details
Main Authors: Debbie A Lawlor, Marianne Benn, Luisa Zuccolo, N Maneka G De Silva, Anne Tybjaerg-Hansen, George Davey Smith, Børge G Nordestgaard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4266606?pdf=render

Internet

http://europepmc.org/articles/PMC4266606?pdf=render

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