Validation of Quantitative Structure-Activity Relationship (QSAR) Model for Photosensitizer Activity Prediction

Validation of Quantitative Structure-Activity Relationship (QSAR) Model for Photosensitizer Activity Prediction

Photodynamic therapy is a relatively new treatment method for cancer which utilizes a combination of oxygen, a photosensitizer and light to generate reactive singlet oxygen that eradicates tumors via direct cell-killing, vasculature damage and engagement of the immune system. Most of photosensitizer...

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Bibliographic Details
Main Authors: Sharifuddin M. Zain, Noorsaadah Abd. Rahman, Rozana Othman, Mun Li Yam, Hong Boon Lee, Neni Frimayanti
Format: Article
Language:English
Published: MDPI AG 2011-11-01
Series:International Journal of Molecular Sciences
Subjects:
QSAR
photodynamic therapy
photosensitizer
porphyrin
IC50 half maximal inhibitory concentration
Online Access:http://www.mdpi.com/1422-0067/12/12/8626/

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http://www.mdpi.com/1422-0067/12/12/8626/

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