Synthesis and Biological Evaluation of HDAC Inhibitors With a Novel Zinc Binding Group

Synthesis and Biological Evaluation of HDAC Inhibitors With a Novel Zinc Binding Group

Vorinostat (SAHA) with great therapeutic potential has been approved by the FDA for the treatment of cutaneous T-cell lymphoma as the first HDACs inhibitor, but the drawbacks associated with hydroxamic acid group (poor stability, easy metabolism, weak binding ability to class IIa isozymes, and poor...

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Bibliographic Details
Main Authors: Junquan He, Songsong Wang, Xingang Liu, Ruili Lin, Fang Deng, Zhong Jia, Chenghong Zhang, Zhao Li, Hongtian Zhu, Lei Tang, Pingrong Yang, Dian He, Qingzhong Jia, Yang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Chemistry
Subjects:
HDAC inhibitor
Novel ZBGs
Anti-tumor
Molecular docking
MD simulation
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00256/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00256/full

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