A Single Step in vitro Bioassay Mimicking TLR4-LPS Pathway and the Role of MD2 and CD14 Coreceptors

A Single Step in vitro Bioassay Mimicking TLR4-LPS Pathway and the Role of MD2 and CD14 Coreceptors

Acute systemic Gram-negative bacterial infections are accompanied by release of lipopolysaccharide (LPS) endotoxins into the bloodstream and an innate immune host response via the well-known toll like receptor 4 (TLR4) pathway. In this, LPS associates non-covalently with TLR4 to form an activated he...

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Bibliographic Details
Main Authors: Pramod Jagtap, Puja Prasad, Abhishek Pateria, Sachin D. Deshmukh, Shalini Gupta
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
TLR4
MD2
CD14
LPS
ligand screening
in vitro bioassay
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00005/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00005/full

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