ELAVL1 Modulates Transcriptome-wide miRNA Binding in Murine Macrophages

Posttranscriptional gene regulation by miRNAs and RNA binding proteins (RBP) is important in development, physiology, and disease. To examine the interplay between miRNAs and the RBP ELAVL1 (HuR), we mapped miRNA binding sites at the transcriptome-wide scale in wild-type and Elavl1 knockout murine b...

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Bibliographic Details
Main Authors: Yi-Chien Lu, Sung-Hee Chang, Markus Hafner, Xi Li, Thomas Tuschl, Olivier Elemento, Timothy Hla
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714009966