Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma.

Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma.

Glaucoma is the world's second leading cause of bilateral blindness with progressive loss of vision due to retinal ganglion cell death. Myocilin has been associated with congenital glaucoma and 2-4% of primary open angle glaucoma (POAG) cases, but the pathogenic mechanisms remain largely unknow...

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Bibliographic Details
Main Authors: Mary Anna Carbone, Julien F Ayroles, Akihiko Yamamoto, Tatiana V Morozova, Steven A West, Michael M Magwire, Trudy F C Mackay, Robert R H Anholt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2615221?pdf=render

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http://europepmc.org/articles/PMC2615221?pdf=render

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