Epithelial-Mesenchymal Transition in Metastatic Cancer Cell Populations Affects Tumor Dormancy in a Simple Mathematical Model

Epithelial-Mesenchymal Transition in Metastatic Cancer Cell Populations Affects Tumor Dormancy in a Simple Mathematical Model

Signaling from the c-Met receptor tyrosine kinase is associated with progression and metastasis of epithelial tumors. c-Met, the receptor for hepatocyte growth factor, triggers epithelial-mesenchymal transition (EMT) of cultured cells, which is thought to drive migration of tumor cells and confer on...

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Bibliographic Details
Main Authors: Adam L. MacLean, Heather A. Harrington, Michael P. H. Stumpf, Marc D. H. Hansen
Format: Article
Language:English
Published: MDPI AG 2014-12-01
Series:Biomedicines
Subjects:
cancer growth
metastasis
chemotherapy
mathematical modeling
Online Access:http://www.mdpi.com/2227-9059/2/4/384

Internet

http://www.mdpi.com/2227-9059/2/4/384

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