Trophoblast Stem-Cell-Derived Exosomes Improve Doxorubicin-Induced Dilated Cardiomyopathy by Modulating the let-7i/YAP Pathway

Trophoblast Stem-Cell-Derived Exosomes Improve Doxorubicin-Induced Dilated Cardiomyopathy by Modulating the let-7i/YAP Pathway

Trophoblast stem cells (TSCs) have been confirmed to play a cardioprotective role in heart failure. However, whether TSC-derived exosomes (TSC-exos) can protect against cardiac injury remains unclear. In the present study, TSC-exos were isolated from the supernatant of TSCs using the ultracentrifuga...

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Bibliographic Details
Main Authors: Jie Ni, Yihai Liu, Kun Wang, Mingyue Wu, Lina Kang, Dujuan Sha, Biao Xu, Rong Gu
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
trophoblast stem cells
exosomes
let-7i
YAP
heart failure
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120303267

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http://www.sciencedirect.com/science/article/pii/S2162253120303267

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