Timing of Treatment with the Flavonoid 7,8-DHF Critically Impacts on Its Effects on Learning and Memory in the Ts65Dn Mouse

Timing of Treatment with the Flavonoid 7,8-DHF Critically Impacts on Its Effects on Learning and Memory in the Ts65Dn Mouse

No therapies currently exist for intellectual disability in Down syndrome (DS). In view of its similarities with DS, including learning and memory (L&M) defects, the Ts65Dn mouse model of DS is widely used for the design of therapy. 7,8-dihydroxyflavone (7,8-DHF), a flavonoid that targets th...

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Bibliographic Details
Main Authors: Andrea Giacomini, Fiorenza Stagni, Marco Emili, Beatrice Uguagliati, Roberto Rimondini, Renata Bartesaghi, Sandra Guidi
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Antioxidants
Subjects:
Down syndrome
Ts65Dn mouse
Cognitive impairment
Therapy
Flavonoids
7,8-dihydroxyflavone
Learning and memory
Online Access:https://www.mdpi.com/2076-3921/8/6/163

Internet

https://www.mdpi.com/2076-3921/8/6/163

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