The PTEN/PI3K/AKT Pathway in vivo, cancer mouse models
PTEN negatively regulates PI3K signalling by dephosphorylating PIP3 to PIP2. AKT is activated downstream of PIP3 to mediate physiologic processes. Furthermore, substantial crosstalk exists with other signalling networks at all levels of the PI3K pathway. As a consequence of diverse gene mutations a...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-09-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00252/full |