Complex structural rearrangements are present in high-grade dysplastic Barrett’s oesophagus samples

Complex structural rearrangements are present in high-grade dysplastic Barrett’s oesophagus samples

Abstract Background Oesophageal adenocarcinoma (EAC) incidence is increasing and has a poor survival rate. Barrett’s oesophagus (BE) is a precursor condition that is associated with EAC and often occurs in conjunction with chronic gastro-oesophageal reflux, however many individuals diagnosed with BE...

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Bibliographic Details
Main Authors: Felicity Newell, Kalpana Patel, Michael Gartside, Lutz Krause, Sandra Brosda, Lauren G. Aoude, Kelly A. Loffler, Vanessa F. Bonazzi, Ann-Marie Patch, Stephen H. Kazakoff, Oliver Holmes, Qinying Xu, Scott Wood, Conrad Leonard, Guy Lampe, Reginald V. Lord, David C. Whiteman, John V. Pearson, Katia Nones, Nicola Waddell, Andrew P. Barbour
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Medical Genomics
Subjects:
Oesophageal adenocarcinoma
Barrett’s oesophagus
Chromothripsis
Breakage-fusion bridge
Whole-genome sequencing
Online Access:http://link.springer.com/article/10.1186/s12920-019-0476-9

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http://link.springer.com/article/10.1186/s12920-019-0476-9

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