Design, ecofriendly synthesis, anticancer and antimicrobial screening of innovative Biginelli dihydropyrimidines using β-aroylpyruvates as synthons

Design, ecofriendly synthesis, anticancer and antimicrobial screening of innovative Biginelli dihydropyrimidines using β-aroylpyruvates as synthons

New ecofriendly Biginelli reaction procedures have been adapted to prepare new dihydropyrimidines (DHPMs) using a multicomponent one-pot reaction. All the synthesized compounds were evaluated for their anticancer activity against 59 human cancer cell lines and evaluated for their antimicrobial activ...

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Bibliographic Details
Main Authors:	Afaf El-Malah, Zeinab Mahmoud, Heba Hamed Salem, Amr M. Abdou, Mona M. H. Soliman, Rasha A. Hassan
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2021-04-01
Series:	Green Chemistry Letters and Reviews
Subjects:	2-thioxo-1,2,3,6-tetrahydropyrimidine 4-carboxylate esters biginelli reaction β-aroylpyruvates anticancer activity antimicrobial activity
Online Access:	http://dx.doi.org/10.1080/17518253.2021.1896789

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