Composition and Function of Mutant Swi/Snf Complexes

Composition and Function of Mutant Swi/Snf Complexes

Summary: The 12-subunit Swi/Snf chromatin remodeling complex is conserved from yeast to humans. It functions to alter nucleosome positions by either sliding nucleosomes on DNA or evicting histones. Interestingly, 20% of all human cancers carry mutations in subunits of the Swi/Snf complex. Many of th...

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Bibliographic Details
Main Authors: Arnob Dutta, Mihaela Sardiu, Madelaine Gogol, Joshua Gilmore, Daoyong Zhang, Laurence Florens, Susan M. Abmayr, Michael P. Washburn, Jerry L. Workman
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301158

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http://www.sciencedirect.com/science/article/pii/S2211124717301158

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