Metformin and 4SC‐202 synergistically promote intrinsic cell apoptosis by accelerating ΔNp63 ubiquitination and degradation in oral squamous cell carcinoma

Metformin and 4SC‐202 synergistically promote intrinsic cell apoptosis by accelerating ΔNp63 ubiquitination and degradation in oral squamous cell carcinoma

Abstract Oral squamous cell carcinoma (OSCC) is the most common and aggressive epithelial tumor in the head and neck region with a rising incidence. Despite the advances in basic science and clinical research, the overall survival rate of OSCC remains low. Thus finding novel effective therapeutic ag...

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Bibliographic Details
Main Authors: Yuan He, Shanshan Tai, Miao Deng, Zhaona Fan, Fan Ping, Lihong He, Chi Zhang, Yulei Huang, Bin Cheng, Juan Xia
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Cancer Medicine
Subjects:
4SC‐202
apoptosis
metformin
oral squamous cell carcinoma
ΔNp63
Online Access:https://doi.org/10.1002/cam4.2206

Internet

https://doi.org/10.1002/cam4.2206

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