Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions

Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions

Vascular endothelial growth factor (VEGF) has potent angiogenic and neuroprotective effects in the ischemic brain. Its effect on axonal plasticity and neurological recovery in the post-acute stroke phase was unknown. Using behavioral tests combined with anterograde tract tracing studies and with imm...

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Bibliographic Details
Main Authors: Josephine Herz, Raluca Reitmeir, Sabine I. Hagen, Barbara S. Reinboth, Zeyun Guo, Anil Zechariah, Ayman ElAli, Thorsten R. Doeppner, Marco Bacigaluppi, Stefano Pluchino, Ülkan Kilic, Ertugrul Kilic, Dirk M. Hermann
Format: Article
Language:English
Published: Elsevier 2012-03-01
Series:Neurobiology of Disease
Subjects:
Brain plasticity
Axonal sprouting
Ischemic stroke
Neuroprotection
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111004013

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http://www.sciencedirect.com/science/article/pii/S0969996111004013

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