Combined transfection of Bcl-2 siRNA and miR-15a oligonucleotides enhanced methotrexate-induced apoptosis in Raji cells

Combined transfection of Bcl-2 siRNA and miR-15a oligonucleotides enhanced methotrexate-induced apoptosis in Raji cells

<b>Objective:</b>B-cell lymphoma 2 (Bcl-2) is an important member of the Bcl-2 family of proteins that regulate the induction of apoptosis. This study aims to investigate whether Bcl-2 small interfering RNA (siRNA) combined with miR-15a oligonucleotides (ODN) could enhance methotrexate (...

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Bibliographic Details
Main Authors: Li Ding, Xiao-Mao Hu, Hong Wu, Ge-Xiu Liu, Yang-Jun Gao, Dong-Mei He, Yuan Zhang
Format: Article
Language:English
Published: China Anti-Cancer Association 2013-03-01
Series:Cancer Biology & Medicine
Subjects:
B-cell lymphoma 2 (Bcl-2)
small interfering RNA
oligonucleotide
methotrexate
Raji cell
miR-15a
apoptosis
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/586

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/586

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