The Significance of IL-36 Hyperactivation and IL-36R Targeting in Psoriasis

The Significance of IL-36 Hyperactivation and IL-36R Targeting in Psoriasis

Psoriasis is an immune-mediated inflammatory skin disease that involves mainly T helper (Th)17, Th1 and Th22 lymphocytes, which cause hyper-proliferation of the epidermis with aberrant differentiation of keratinocytes, and local production of chemokines and cytokines. These fuel a self-amplifying lo...

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Bibliographic Details
Main Authors: Stefania Madonna, Giampiero Girolomoni, Charles A. Dinarello, Cristina Albanesi
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
psoriasis
IL-36
IL-38
IL-17
skin inflammation
Online Access:https://www.mdpi.com/1422-0067/20/13/3318

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https://www.mdpi.com/1422-0067/20/13/3318

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