Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells

Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells

Summary: Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-associated surface molecules. Using single-cell RNA seque...

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Bibliographic Details
Main Authors: Samuel W. Lukowski, Inga Rødahl, Samuel Kelly, Meihua Yu, James Gotley, Chenhao Zhou, Susan Millard, Stacey B. Andersen, Angelika N. Christ, Gabrielle Belz, Ian H. Frazer, Janin Chandra
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:iScience
Subjects:
Immunology
Cell Biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221003709

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http://www.sciencedirect.com/science/article/pii/S2589004221003709

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