Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration.

Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration.

BACKGROUND:Age-related macular degeneration (AMD), a chronic neurodegenerative and neovascular retinal disease, is the leading cause of blindness in elderly people of western European origin. While structural and functional alterations in mitochondria (mt) and their metabolites have been implicated...

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Bibliographic Details
Main Authors: John Paul SanGiovanni, Dan E Arking, Sudha K Iyengar, Michael Elashoff, Traci E Clemons, George F Reed, Alice K Henning, Theru A Sivakumaran, Xuming Xu, Andrew DeWan, Elvira Agrón, Elena Rochtchina, Carolyn M Sue, Jie Jin Wang, Paul Mitchell, Josephine Hoh, Peter J Francis, Michael L Klein, Emily Y Chew, Aravinda Chakravarti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2677106?pdf=render

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http://europepmc.org/articles/PMC2677106?pdf=render

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