SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity

SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the Angiotensin converting enzyme 2 (ACE2) receptor present on the cell surface to enter cells. Angiotensin converting enzyme 2 is present in many cell types including endothelial cells, where it functions to protect against oxidative...

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Bibliographic Details
Main Authors: Somasundaram Raghavan, Divya Borsandra Kenchappa, M. Dennis Leo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
endothelial barrier function
SARS-CoV-2
angiotensin converting enzyme-2
spike
junctional proteins
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.687783/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.687783/full

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