Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics

Characterisation of early changes in ovine CLN5 and CLN6 Batten disease neural cultures for the rapid screening of therapeutics

Batten disease (neuronal ceroid lipofuscinosis) refers to a group of neurodegenerative lysosomal storage diseases predominantly affecting children. There are currently no effective treatments, and the functions of many of the associated gene products are unknown. Here we characterise fetal neural cu...

Full description

Bibliographic Details
Main Authors: Hannah L Best, Nicole J Neverman, Hollie E Wicky, Nadia L Mitchell, Beulah Leitch, Stephanie M Hughes
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Neurobiology of Disease
Subjects:
Batten disease
Neuronal ceroid lipofuscinosis
CLN5
CLN6
Neuronal cell culture
Gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117300013

Internet

http://www.sciencedirect.com/science/article/pii/S0969996117300013

Similar Items