The BEACH Domain Is Critical for Blue Cheese Function in a Spatial and Epistatic Autophagy Hierarchy

The BEACH Domain Is Critical for Blue Cheese Function in a Spatial and Epistatic Autophagy Hierarchy

Drosophila blue cheese (bchs) encodes a BEACH domain adaptor protein that, like its human homolog ALFY, promotes clearance of aggregated proteins through its interaction with Atg5 and p62. bchs mutations lead to age-dependent accumulation of ubiquitinated inclusions and progressive neurodegeneration...

Full description

Bibliographic Details
Main Authors: Joan Sim, Kathleen A. Osborne, Irene Argudo García, Artur S. Matysik, Rachel Kraut
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
blue cheese
Drosophila
autophagy
BEACH domain
motor neuron
neurodegeneration
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00129/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00129/full

Similar Items