Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1

Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1

Stimulation of the ubiquitin-proteasome pathway—especially E3 ubiquitin ligases Atrogin-1 and MuRF1—is associated with muscle loss in diabetes. Elevated lipid metabolites impair myogenesis. Oligonol, a low molecular weight polyphenol derived from lychee, exhibited anti-diabetic and anti-obesity prop...

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Bibliographic Details
Main Authors: Hung-Wen Liu, Yen-Ju Chen, Yun-Ching Chang, Sue-Joan Chang
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Nutrients
Subjects:
diabetes
Atrogin-1 and MuRF1
flavanol-rich lychee fruit extract
muscle loss
NF-κB
Online Access:https://www.mdpi.com/2072-6643/9/9/1040

Internet

https://www.mdpi.com/2072-6643/9/9/1040

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