Using connectivity map to identify natural lignan justicidin A as a NF-κB suppressor

Using connectivity map to identify natural lignan justicidin A as a NF-κB suppressor

Justicidin A (JA), a natural lignan, was isolated from the whole plant of Justicia procumbens, one of the most popular traditional Chinese medicines in China and Taiwan. Gene expression signatures of JA from human colorectal cancer HT-29 and hepatocellular carcinoma Hep 3B cells were used to query c...

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Bibliographic Details
Main Authors: Shen-Jeu Won, Cheng-Hsin Yen, Hao-Wen Hsieh, Shao-Wei Chang, Chun-Nan Lin, Chi-Ying F. Huang, Chun-Li Su
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Journal of Functional Foods
Subjects:
Justicidin A
NF-κB
Caspase-independent apoptosis
L1000 gene expression profiling
Connectivity map
Human colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464617302062

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http://www.sciencedirect.com/science/article/pii/S1756464617302062

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