Variation at FCGR2A and functionally related genes is associated with the response to anti-TNF therapy in rheumatoid arthritis.

Variation at FCGR2A and functionally related genes is associated with the response to anti-TNF therapy in rheumatoid arthritis.

<h4>Objective</h4>Anti-TNF therapies have been highly efficacious in the management of rheumatoid arthritis (RA), but 25-30% of patients do not show a significant clinical response. There is increasing evidence that genetic variation at the Fc receptor FCGR2A is associated with the respo...

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Bibliographic Details
Main Authors: Gabriela Avila-Pedretti, Jesús Tornero, Antonio Fernández-Nebro, Francisco Blanco, Isidoro González-Alvaro, Juan D Cañete, Joan Maymó, Mercedes Alperiz, Benjamín Fernández-Gutiérrez, Alex Olivé, Héctor Corominas, Alba Erra, Adrià Aterido, María López Lasanta, Raül Tortosa, Antonio Julià, Sara Marsal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0122088

Internet

https://doi.org/10.1371/journal.pone.0122088

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