Induction of Apoptosis, G0/G1 Phase Arrest and Microtubule Disassembly in K562 Leukemia Cells by Mere15, a Novel Polypeptide from Meretrix meretrix Linnaeus

Induction of Apoptosis, G0/G1 Phase Arrest and Microtubule Disassembly in K562 Leukemia Cells by Mere15, a Novel Polypeptide from Meretrix meretrix Linnaeus

Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC50 values of 38.2 μg/mL. Mere15 also caus...

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Bibliographic Details
Main Authors: Xiukun Lin, Ning Wu, Linyou Cheng, Jin Zhao, Haizhou Liu, Lin Xiao, Cuicui Wang, Xiangzhong Zhao, Ming Liu
Format: Article
Language:English
Published: MDPI AG 2012-11-01
Series:Marine Drugs
Subjects:
Meretrix meretrix Linnaeus
Mere15
apoptosis
anticancer
Online Access:http://www.mdpi.com/1660-3397/10/11/2596

Internet

http://www.mdpi.com/1660-3397/10/11/2596

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