Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic Mice.

Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic Mice.

Diabetes mellitus is characterized by changes in endothelial cells that alter monocyte recruitment, increase classic (M1-type) tissue macrophage infiltration and lead to self-sustained inflammation. Our and other groups recently showed that chronic inhibition of phosphodiesterase-5 (PDE5i) affects c...

Full description

Bibliographic Details
Main Authors: Mary Anna Venneri, Elisa Giannetta, Giuseppe Panio, Rita De Gaetano, Daniele Gianfrilli, Riccardo Pofi, Silvia Masciarelli, Francesco Fazi, Manuela Pellegrini, Andrea Lenzi, Fabio Naro, Andrea M Isidori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4427327?pdf=render

Internet

http://europepmc.org/articles/PMC4427327?pdf=render

Similar Items