Upfront Cranial Radiotherapy vs. EGFR Tyrosine Kinase Inhibitors Alone for the Treatment of Brain Metastases From Non-small-cell Lung Cancer: A Meta-Analysis of 1465 Patients

Upfront Cranial Radiotherapy vs. EGFR Tyrosine Kinase Inhibitors Alone for the Treatment of Brain Metastases From Non-small-cell Lung Cancer: A Meta-Analysis of 1465 Patients

Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is revolutionizing the management of brain metastases (BMs). This study was to explore the value of upfront cranial radiotherapy (RT) in EGFR-mutated non-small cell lung cancer (NSCLC) with BMs compared with EGFR-TKI...

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Bibliographic Details
Main Authors: Xiao-Jing Du, Su-Ming Pan, Shu-Zhen Lai, Xiao-Nan Xu, Mei-Ling Deng, Xiao-Hui Wang, Dun-Chen Yao, Shao-Xiong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Oncology
Subjects:
non-small-cell lung cancer
whole brain radiation therapy
stereotactic radiosurgery
epidermal growth factor receptor
tyrosine kinase inhibitors
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00603/full

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https://www.frontiersin.org/article/10.3389/fonc.2018.00603/full

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